Review on Clinical Trials of Black Seed Nigella sativa and Its Active Constituent, Thymoquinone PMC
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Additionally, administration of the crushed seeds caused a significant increase in the white blood cell count (WBC) and the hemoglobin level whereas administration of NS oil only increased the hemoglobin level significantly [51]. In another study, Bamosa et al suggested that the administration of NS at 2 g/day for 2 weeks decreased the blood levels of both glucose and cholesterol in healthy volunteers [70]. Having cytoprotective actions against numerous adverse stimuli, black cumin seed exhibits cardioprotective effects (Table 5). For instance, post-conditioning with black cumin improved cardiac functions against I/R-induced cardiac injury by mitigating oxidative stress [143].
Nigella Sativa (Black Cumin) Seed Oil
Huseini et al showed that as compared with the topical administration of diclofenac, topical administration of NS oil had significant therapeutic effects on patients with cyclic mastalgia without any adverse effects [86]. In that study, 600 mg of NS oil (in the first treatment group) and 20 mg of topical diclofenac (in the second treatment group) were applied to the painful area twice daily for two months. The effects of NS and TQ on different components of metabolic syndrome and cardiovascular disease risk factors, including high BP, obesity, dyslipidemia, and high blood glucose, have been established [21]. The clinical uses of NS and TQ in the prevention and treatment of these factors will be discussed in subsequent subsections.
Cyclosporine (Neoral, Sandimmune) interacts with BLACK SEED
Pylori effect comparable to triple therapy [109] and this can provide a scientific basis for the exploration of potential uses of this valued seed for the treatment of H. In another study, which was undertaken on patients with inhalation allergy, the beneficial impacts of NS oil on the immune status of those patients, including enhancement of the NK cell count and percentage of lymphocytes, were confirmed [103]. Infection with HCV often leads to chronic hepatitis, which, in turn, results in liver cirrhosis and hepatocellular carcinomas. A study conducted in Egypt on HCV patients demonstrated that ethanolic extracts of NS and Zingiber officinale (Z. officinale), alone and together, had beneficial effects on HCV patients; i.e., their liver function was improved and the viral load was decreased [90]. In that study, a mixture of these extracts was observed to be more effective than each one alone.
What Is Black Seed?
Black cumin seeds also contain significant levels of iron, copper, zinc, phosphorus, calcium, thiamin, niacin, pyridoxine, and folic acid [7, 8]. Sativa displayed the presence of over hundreds of phytoconstituents which include mainly alkaloids, saponins, sterols, and essential oil but the composition of many of these have not been chemically recognized nor have been biologically verified. Sativa seed contain 26-34% fixed oil of which the major fatty acids are linoleic acid (64.6%) and palmitic acid (20.4%). Amongst different active constituents reported so far, thymoquinone found as major component of the essential oil is the most bioactive compound and exhibits wide ranging therapeutic benefits [11]. In a study conducted on children who were infected with cestodes, the efficacy of single oral administration of NS powdered seeds and ethanolic extract (40 mg/kg body weight) was proven to reduce the percentage of fecal eggs per gram, which means NS has an anti-cestodal effect [45]. Furthermore, in a RCT in which 100 infected women were included, the therapeutic effects of black seed capsules (500 mg twice daily) used together with clotrimazole vaginal cream on C.
- Black cumin is traditionally used by the lactating mother due to its promotional effect on milk production.
- This review covers those articles that demonstrate the health benefits of black cumin alone or its compounds or both.
- Qidwai et al reported that the administration https://nigellaltd.com/za-nas/ of NS seeds (2 g/day for 6 weeks) did not affect the serum alanine aminotransferase (ALT) or the serum creatinine (Cr) levels in adults [34].
- In their two successive studies, Shao and the team reported that TQ attenuated convulsion and improved learning and memory function in lithium-pilocarpine induced models of status epilepticus via anti-inflammatory (NF-κB) [70] and antioxidant (Nrf2/HO-1) [69] signaling pathways.
- Black cumin seeds have a similar but milder flavour than cumin seeds.
Where Is Our Black Cumin Seed From
Furthermore, in another clinical trial, in which 15 osteoporotic postmenopausal women were included, no beneficial effects of consuming NS extract (0.05 mL/kg/d for three months) on bone turnover were observed [105]. Obesity, defined as excess fat mass, increases the risks for multiple metabolic diseases, such as type 2 diabetes, cardiovascular disease, and several types of cancer [60]. Some RCTs demonstrated that NS oil in combination with a low-calorie diet decreased weight in obese women in comparison to the placebo level [61, 62]. It also caused the superoxide dismutase (SOD) level to be elevated [61] and the TG and the LDL-C levels to be decreased [62]. Apart from individual effects, when applied in combination with other compounds or natural products, black cumin or TQ potentiates their biological activity, as well as synergizes the effects, reducing the dose size of the concurrently used drugs and minimizing the likely toxicity. However, the pharmacological interactions that occur when used concomitantly with other compounds have been highlighted so that further research in the future does not overlook this critical issue in the path to the development of a successful drug.
Associated Data
So, alternative treatments like black cumin seeds could be an effective way to fight these bacteria. Animal studies show that black seeds can help prevent cognitive decline. Nigella seeds are a powerhouse of various nutrients that help sharpen your memory and improve cognitive functions.
Sativa can affect oxidative phosphorylation enzymes and increase sperm motility [147]. In addition, a randomized, double-blind, placebo-controlled clinical trial was conducted on 68 Iranian infertile men and half of them receive 2.5 mL of black seed oil and the remaining received placebo twice daily for two months. The amount and the motility of sperm and the content of semen volume were raised significantly in black seed oil treated group compared with placebo group after two months of therapy [148]. Sativa can be a potential source for development of natural aphrodisiac agents. In conclusion, the use of black seeds and their active constituent TQ has been shown to have multiple useful effects in the treatments of patients with several diseases, such as inflammatory and auto-immune disorders, as well as metabolic syndrome.
Grapeseed Oil
The repeat serology assessments for HIV infection became negative with undetectable viral load. The woman also got 3 children (2007, 2010, and 2012) that all were breastfed and none of the children infected with HIV and her repeat CD4 count was not less than 750 cells/μL [118]. Sativa can be a promising natural therapy to cure such a chronic infectious disease, after validating its full therapeutic efficacy by further investigations. Sativa of different origins has been reported to possess moderate inhibitory action against pathogenic strains of yeasts, dermatophytes and nondermatophytic filamentous fungi along with aflatoxin-producing fungi.
So next time you buy whole spices, you won’t have to ask the storekeeper or check on Google again to purchase the right seeds. Black seed may be good for acne, asthma, hay fever and allergies, diabetes, weight loss, high blood pressure, pain, and other health concerns. But another plant, Bunium bulbocastanum, is also called black cumin.
Sativa treatment targeted the cell wall, plasma membrane, and membranous organelles, mainly in the nuclei and mitochondria as were evident in the morphology of these toxigenic fungi [110]. Moreover, different extracts of black cumin and TQ exhibited powerful fungicidal activity against dermatophyte strains including Trichophyton mentagrophytes and Microsporum gypseum superior to fluconazole, but lesser than that of ketoconazole [111]. Thymoquinone also arrested the growth of Aspergillus niger and Fusarium solani comparable to Amphotericin-B [112] and was effective against C.
What are the warnings of cumin?
Cumin might slow blood clotting, which might make bleeding disorders worse. Surgery: Cumin might lower blood sugar levels and slow blood clotting. It might interfere with blood sugar control and make bleeding worse during and after surgery.
Is black cumin good for hair?
The essential fatty acids present in black cumin oil, such as omega-3 and omega-6, help nourish the hair shaft, improving its strength and elasticity. This can reduce breakage, split ends, and hair damage, resulting in healthier and more lustrous locks.
Does black seed oil interact with any medications?
Black seed can increase the activity of the immune system. Some medications, such as those used after a transplant, decrease the activity of the immune system. Taking black seed along with these medications might decrease the effects of these medications. Black seed might increase a brain chemical called serotonin.